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National Repository of Grey Literature 2 records found  Search took 0.01 seconds. 
Neuropeptide Y and food intake regulation
 Váchová, Barbora ; Nedvídková, Jara (advisor) ; Telenský, Petr (referee)
Neuropeptide Y (NPY) is a 36-amino acid member of NPY family. Its biosynthesis occurs in the hypothalamus and its expression also in adipose tissue was described in 2007. NPY is an ubiquitous hormone with central and peripheral effects which lead to the maintenance of homeostasis; NPY is also one of the most significant orexigenic hormones. NPY utilizes G-protein coupled receptors Y1, Y2 and Y5 for its food intake regulation; owing to serious side effects of currently used anti-obesity drugs, the ligands of these receptors (Y1R and Y5R antagonists and Y2R agonists) are considered as targeting molecules for a new therapeutic strategy for obesity treatment. This work is focused on the characteristic of NPY as an orexigenic agent and the possibility of using NPY-based drugs for obesity treatment.
Detailed record
Neuropeptide Y and food intake regulation
 Váchová, Barbora ; Telenský, Petr (referee) ; Nedvídková, Jara (advisor)
Neuropeptide Y (NPY) is a 36-amino acid member of NPY family. Its biosynthesis occurs in the hypothalamus and its expression also in adipose tissue was described in 2007. NPY is an ubiquitous hormone with central and peripheral effects which lead to the maintenance of homeostasis; NPY is also one of the most significant orexigenic hormones. NPY utilizes G-protein coupled receptors Y1, Y2 and Y5 for its food intake regulation; owing to serious side effects of currently used anti-obesity drugs, the ligands of these receptors (Y1R and Y5R antagonists and Y2R agonists) are considered as targeting molecules for a new therapeutic strategy for obesity treatment. This work is focused on the characteristic of NPY as an orexigenic agent and the possibility of using NPY-based drugs for obesity treatment.
Detailed record

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